Protection of sensitive powders
Active substances and their formulations often have variable sensitivities to moisture, light, and mechanical impact. DirectHaler™ Nasal can accommodate such needs for protection. The powder dose is sealed inside the cap with a laminate foil strip, which is easily torn off for dose-loading into the PowderWhirl chamber, before removing the cap and delivering the dose.
Bi-dose delivery device versions
Some therapeutic applications require delivery of two doses. DirectHaler™ Nasal can be supplied with caps for bi-dose storage and dose-encapsulation, along with customised device appearance; both designed for optimal ease of use.
Building novel combination therapy
The DirectHaler™ Nasal device can be considered as the basic building block in any combination therapy or dosing sequencing involving nasal delivery. This means that the DirectHaler™ Nasal device could be the nasal component in a combination therapy consisting of, for instance: one nasal dose + one oral dose in the same blister pack.
Such innovative combination therapy options, using two delivery routes at the same time, would enable the design of delivery systems that would, for example, achieve:
- Local action (nasal) + systemic action (oral);
- Rapid onset of action (nasal) + delayed and sustained release (oral).
Targeting the complete respiratory system
Dosing to the complete respiratory system has previously only been possible by special nebulisers with facemasks and limited portability. The DirectHaler™ technologies do away with these limitations, opening a completely new option for drug delivery to the whole respiratory system with its dry-powder formulations.
DirectHaler™ Nasal and DirectHaler™ Pulmonary are the first unit-dose devices that can be clicked together as one device, enabling specific dosing to the nasal and pulmonary airways, thereby targeting the complete airway system. Such targeting can be highly relevant in treatment of respiratory diseases, and in the prevention/treatment of respiratory infections (also in relation to biodefence).
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